Literature associating ANGPT2 and hereditary hemorrhagic telangiectasia
Angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal; Fibrinogen C domain containing
Synonyms: ANGPT2, ANGPT2p, hANGPT2, ANGIOPOIETIN-2, ANGIOPOIETIN-2-001 ...