Disease-gene associations mined from literature

Literature associating UACA and Graves' disease

UACA [ENSP00000314556]

Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity); Ankyrin repeat domain containing

Synonyms:  UACA,  DKFZP564M063,  F5H2B9,  H0YMI1,  H0YN48 ...

Linkouts:  STRING  Pharos  UniProt  OMIM