Literature associating SNX14 and hereditary spastic paraplegia 49
Sorting nexin 14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes (Probable). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)); Sorting nexins
Synonyms: SNX14, SNX14p, hSNX14, D6RBA7, D6RDA6 ...