Literature associating CFLAR and colon adenocarcinoma
Caspase-like apoptosis regulatory protein; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity; Belongs to the peptidase C14A family.
Synonyms: CFLAR, A0A024R3Y3, A0A024R3Z7, C9J408, C9J4Q0 ...