DISEASES

Disease-gene associations mined from literature

Literature associating MSL3 and atrial heart septal defect 3

MSL3 [ENSP00000312244]

Male-specific lethal 3 homolog (Drosophila); May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex.

Synonyms:  MSL3,  MSL3p,  hMSL3,  A6NLU8,  B4E2T7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM