DISEASES

Disease-gene associations mined from literature

Literature associating REST and Rett syndrome

REST [ENSP00000311816]

Neural-restrictive silencer factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Synonyms:  REST,  L0B1S6,  L0B3Z2,  Q13127,  REST-001 ...

Linkouts:  STRING  Pharos  UniProt  OMIM