DISEASES

Disease-gene associations mined from literature

Literature associating CMKLR1 and demyelinating disease

CMKLR1 [ENSP00000311733]

G-protein coupled receptor ChemR23; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

Synonyms:  CMKLR1,  CMKLR1p,  hCMKLR1,  F8VSC8,  F8VYN7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM