DISEASES

Disease-gene associations mined from literature

Literature associating CYP7B1 and hereditary spastic paraplegia 35

CYP7B1 [ENSP00000310721]

Cytochrome P450, family 7, subfamily B, polypeptide 1; Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol. Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (By similarity); Cytochrome P450 family 7

Synonyms:  CYP7B1,  CYP7B1p,  hCYP7B1,  O75881,  O75881p ...

Linkouts:  STRING  Pharos  UniProt  OMIM