DISEASES

Disease-gene associations mined from literature

Literature associating KCNE3 and familial atrial fibrillation

KCNE3 [ENSP00000310557]

Potassium voltage-gated channel, Isk-related family, member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship.

Synonyms:  KCNE3,  KCNE3p,  hKCNE3,  E9PJV9,  E9PN03 ...

Linkouts:  STRING  Pharos  UniProt  OMIM