Literature associating RASGRP1 and leukocyte adhesion deficiency 3
Calcium and DAG-regulated guanine nucleotide exchange factor II; Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B- lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM- dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types; Belongs to the RASGRP family.
Synonyms: RASGRP1, RASGRP1p, hRASGRP1, F5H514, H0YKM0 ...