Disease-gene associations mined from literature

Literature associating RAB1B and legionellosis

RAB1B [ENSP00000310226]

Ras-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum . Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).

Synonyms:  RAB1B,  RAB1Bp,  hRAB1B,  E9PLD0,  Q9H0U4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM