DISEASES

Disease-gene associations mined from literature

Literature associating ADAM17 and endocrine gland cancer

ADAM17 [ENSP00000309968]

Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2; ADAM metallopeptidase domain containing

Synonyms:  ADAM17,  ADAM17p,  hADAM17,  A6H8L4,  B2RNB2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM