Literature associating SH3PXD2B and ametropic amblyopia
Tyrosine kinase substrate with four SH3 domains; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).
Synonyms: SH3PXD2B, A1X283, G3V144, A1X283p, hA1X283 ...