Literature associating UBE3C and distal hereditary motor neuronopathy type 1
HECT-type ubiquitin transferase E3C; E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.
Synonyms: UBE3C, UBE3Cp, hUBE3C, H7C0Y1, Q15386 ...