Disease-gene associations mined from literature

Literature associating MLKL and maxillary sinus inverted papilloma

MLKL [ENSP00000308351]

Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Synonyms:  MLKL,  I3L2T9,  I3L4Z5,  Q8NB16,  I3L2T9p ...

Linkouts:  STRING  Pharos  UniProt  OMIM