Disease-gene associations mined from literature

Literature associating MUS81 and karyomegalic interstitial nephritis

MUS81 [ENSP00000307853]

MUS81 structure-specific endonuclease subunit; Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks; Belongs to the XPF family.

Synonyms:  MUS81,  MUS81p,  hMUS81,  E9PII7,  E9PL60 ...

Linkouts:  STRING  Pharos  UniProt  OMIM