DISEASES

Disease-gene associations mined from literature

Literature associating MRC2 and bone cancer

MRC2 [ENSP00000307513]

Urokinase-type plasminogen activator receptor-associated protein; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix cooperating with the matrix metalloproteinases (MMPs); C-type lectin domain containing

Synonyms:  MRC2,  MRC2p,  hMRC2,  E7EME3,  J3QQZ6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM