DISEASES

Disease-gene associations mined from literature

Literature associating MCM7 and melanoacanthoma

MCM7 [ENSP00000307288]

Minichromosome maintenance complex component 7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.

Synonyms:  MCM7,  MCM7p,  hMCM7,  C9J8M6,  P33993 ...

Linkouts:  STRING  Pharos  UniProt  OMIM