Disease-gene associations mined from literature

Literature associating APLF and Osgood-Schlatter's disease

APLF [ENSP00000307004]

PNK and APTX-like FHA domain-containing protein; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage; Zinc fingers

Synonyms:  APLF,  PROKR1,  E9PRH6,  F8WET0,  PROKR1p ...

Linkouts:  STRING  Pharos  UniProt #1 #2  OMIM