Literature associating APLF and Osgood-Schlatter's disease
PNK and APTX-like FHA domain-containing protein; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage; Zinc fingers
Synonyms: APLF, PROKR1, E9PRH6, F8WET0, PROKR1p ...