Literature associating GRM5 and focal epilepsy
Glutamate receptor, metabotropic 5; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity; Glutamate metabotropic receptors
Synonyms: GRM5, GRM5p, hGRM5, A8K5P7, A8MT20 ...