DISEASES

Disease-gene associations mined from literature

Literature associating IRS1 and obesity

IRS1 [ENSP00000304895]

Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

Synonyms:  IRS1,  IRS1p,  hIRS1,  A0A024R499,  P35568 ...

Linkouts:  STRING  Pharos  UniProt  OMIM