Disease-gene associations mined from literature

Literature associating CD14 and acute monocytic leukemia

CD14 [ENSP00000304236]

Myeloid cell-specific leucine-rich glycoprotein; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-); CD molecules

Synonyms:  CD14,  CD14p,  hCD14,  D6RD81,  D6RFL4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM