DISEASES

Disease-gene associations mined from literature

Literature associating HTRA3 and ovarian cystadenocarcinoma

HTRA3 [ENSP00000303766]

High-temperature requirement factor A3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization; Belongs to the peptidase S1C family.

Synonyms:  HTRA3,  HTRA3p,  hHTRA3,  P83110,  P83110p ...

Linkouts:  STRING  Pharos  UniProt  OMIM