DISEASES

Disease-gene associations mined from literature

Literature associating ZRSR2 and chronic leukemia

ZRSR2 [ENSP00000303015]

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Synonyms:  ZRSR2,  ZRSR2p,  hZRSR2,  A6NDW0,  Q15696 ...

Linkouts:  STRING  Pharos  UniProt  OMIM