DISEASES

Disease-gene associations mined from literature

Literature associating CLEC7A and candidiasis

CLEC7A [ENSP00000302569]

Dendritic cell-associated C-type lectin 1; Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity); C-type lectin domain containing

Synonyms:  CLEC7A,  CLEC7Ap,  hCLEC7A,  A0A024RAN9,  DKFZP686L24211 ...

Linkouts:  STRING  Pharos  UniProt  OMIM