Disease-gene associations mined from literature

Literature associating PRDX2 and Fuchs' endothelial dystrophy

PRDX2 [ENSP00000301522]

Thioredoxin-dependent peroxide reductase 1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2); Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

Synonyms:  PRDX2,  PRDX2p,  hPRDX2,  A6NIW5,  HEL-S-2A ...

Linkouts:  STRING  Pharos  UniProt  OMIM