Literature associating WNT10B and split hand-foot malformation 4
Wingless-type MMTV integration site family, member 10B; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin; Belongs to the Wnt family.
Synonyms: WNT10B, WNT10Bp, hWNT10B, B5MCC8, C9J3H3 ...