DISEASES

Disease-gene associations mined from literature

Literature associating NOD2 and colitis

NOD2 [ENSP00000300589]

Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages; Caspase recruitment domain containing

Synonyms:  NOD2,  NOD2p,  hNOD2,  A3FA72,  A7J384 ...

Linkouts:  STRING  Pharos  UniProt  OMIM