DISEASES

Disease-gene associations mined from literature

Literature associating CRK and pilocytic astrocytoma of cerebellum

CRK [ENSP00000300574]

V-crk avian sarcoma virus CT10 oncogene homolog; Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Synonyms:  CRK,  I3L297,  L7RT18,  P46108,  I3L297p ...

Linkouts:  STRING  Pharos  UniProt  OMIM