DISEASES

Disease-gene associations mined from literature

Literature associating NUDT21 and amebiasis

NUDT21 [ENSP00000300291]

Cleavage and polyadenylation specificity factor 25 kDa subunit; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export; Nudix hydrolase family

Synonyms:  NUDT21,  NUDT21p,  hNUDT21,  A0A024R6W2,  H3BND3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM