DISEASES

Disease-gene associations mined from literature

Literature associating CLEC4E and coccidioidomycosis

CLEC4E [ENSP00000299663]

C-type lectin domain family 4, member E; C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.

Synonyms:  CLEC4E,  CLEC4Ep,  hCLEC4E,  F5H5X7,  F8WFA1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM