DISEASES

Disease-gene associations mined from literature

Literature associating FOLR2 and spina bifida

FOLR2 [ENSP00000298223]

Folate receptor, fetal/placental; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.

Synonyms:  FOLR2,  FOLR2p,  hFOLR2,  E7EU04,  F5GXV3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM