Literature associating FOLR2 and spina bifida
Folate receptor, fetal/placental; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
Synonyms: FOLR2, FOLR2p, hFOLR2, E7EU04, F5GXV3 ...