DISEASES

Disease-gene associations mined from literature

Literature associating DCSTAMP and bone remodeling disease

DCSTAMP [ENSP00000297581]

Dendrocyte expressed seven transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

Synonyms:  DCSTAMP,  Q9H295,  Q9H295p,  hQ9H295,  TM7SF4 ...

Linkouts:  STRING  Pharos  UniProt