DISEASES

Disease-gene associations mined from literature

Literature associating SOX17 and cerebral arterial disease

SOX17 [ENSP00000297316]

SRY (sex determining region Y)-box 17; Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal looping of the embryonic heart tube. Required for normal development of the definitive gut endoderm. Probable transcriptional activator in the premeiotic germ cells (By similarity); SRY-boxes

Synonyms:  SOX17,  SOX17p,  hSOX17,  Q2NKK5,  Q2T9L5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM