DISEASES

Disease-gene associations mined from literature

Literature associating TLR3 and toxic pneumonitis

TLR3 [ENSP00000296795]

Toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response; CD molecules

Synonyms:  TLR3,  TLR3p,  hTLR3,  D6RA51,  O15455 ...

Linkouts:  STRING  Pharos  UniProt  OMIM