Disease-gene associations mined from literature

Literature associating H2AFZ and Floating-Harbor syndrome

H2AFZ [ENSP00000296417]

H2A histone family, member Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Synonyms:  H2AFZ,  H2AFZp,  hH2AFZ,  P0C0S5,  H2AZ ...

Linkouts:  STRING  Pharos  UniProt  OMIM