Literature associating TDGF1 and embryonal carcinoma
Epidermal growth factor-like cripto protein CR1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Synonyms: TDGF1, TDGF1p, hTDGF1, F5H1T8, P13385 ...