Disease-gene associations mined from literature

Literature associating PF4 and thrombocytopenia due to platelet alloimmunization

PF4 [ENSP00000296029]

C-X-C motif chemokine 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form; Belongs to the intercrine alpha (chemokine CxC) family.

Synonyms:  PF4,  PF4p,  hPF4,  P02776,  CXCL4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM