DISEASES

Disease-gene associations mined from literature

Literature associating HESX1 and adamantinous craniopharyngioma

HESX1 [ENSP00000295934]

Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation; Belongs to the ANF homeobox family.

Synonyms:  HESX1,  HESX1p,  hHESX1,  A0A024R364,  C9J0A9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM