DISEASES

Disease-gene associations mined from literature

Literature associating NKX6-1 and permanent neonatal diabetes mellitus

NKX6-1 [ENSP00000295886]

Homeobox protein NK-6 homolog A; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity); NKL subclass homeoboxes and pseudogenes

Synonyms:  NKX6-1,  F8VWZ9,  P78426,  F8VWZ9p,  hF8VWZ9 ...

Linkouts:  STRING  Pharos  UniProt