Disease-gene associations mined from literature

Literature associating BMP10 and heart septal defect

BMP10 [ENSP00000295379]

Bone morphogenetic protein 10; Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines; Belongs to the TGF-beta family.

Synonyms:  BMP10,  BMP10p,  hBMP10,  O95393,  O95393p ...

Linkouts:  STRING  Pharos  UniProt  OMIM