Disease-gene associations mined from literature

Literature associating FRZB and localized osteosarcoma

FRZB [ENSP00000295113]

Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

Synonyms:  FRZB,  D9ZGF6,  Q53QN4,  Q53QT6,  Q92765 ...

Linkouts:  STRING  Pharos  UniProt  OMIM