Disease-gene associations mined from literature

Literature associating NCSTN and hidradenitis

NCSTN [ENSP00000294785]

Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

Synonyms:  NCSTN,  E7ENA9,  Q5T205,  Q5T209,  Q5T210 ...

Linkouts:  STRING  Pharos  UniProt  OMIM