DISEASES

Disease-gene associations mined from literature

Literature associating VCAM1 and venous insufficiency

VCAM1 [ENSP00000294728]

Vascular cell adhesion molecule 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation; C2-set domain containing

Synonyms:  VCAM1,  VCAM1p,  hVCAM1,  DKFZP779G2333,  E9PDD2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM