DISEASES

Disease-gene associations mined from literature

Literature associating TNFSF12 and common variable immunodeficiency

TNFSF12 [ENSP00000293825]

Tumor necrosis factor (ligand) superfamily, member 12; Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion; Tumor necrosis factor superfamily

Synonyms:  TNFSF12,  TNFSF12p,  hTNFSF12,  C0H5Y4,  O43508 ...

Linkouts:  STRING  Pharos  UniProt