DISEASES

Disease-gene associations mined from literature

Literature associating WNT1 and osteogenesis imperfecta

WNT1 [ENSP00000293549]

Wingless-type MMTV integration site family, member 1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters. Has a role in osteoblast function and bone development.

Synonyms:  WNT1,  WNT1p,  hWNT1,  P04628,  INT1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM