DISEASES

Disease-gene associations mined from literature

Literature associating CCR2 and tenosynovial giant cell tumor

CCR2 [ENSP00000292301]

Monocyte chemoattractant protein 1 receptor; Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellular calcium ion levels (By similarity). Upon CCL2 ligation, mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable).

Synonyms:  CCR2,  CCR2p,  hCCR2,  A0A024R2Q0,  B4XH69 ...

Linkouts:  STRING  Pharos  UniProt  OMIM