DISEASES

Disease-gene associations mined from literature

Literature associating MED27 and infratentorial cancer

MED27 [ENSP00000292035]

Cofactor required for Sp1 transcriptional activation subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Synonyms:  MED27,  MED27p,  hMED27,  A0A024R8B7,  CRSP8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM