Disease-gene associations mined from literature

Literature associating KCNE2 and long QT syndrome 9

KCNE2 [ENSP00000290310]

Potassium voltage-gated channel, Isk-related family, member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current.

Synonyms:  KCNE2,  KCNE2p,  hKCNE2,  Q2N1I3,  Q9Y6J6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM