DISEASES

Disease-gene associations mined from literature

Literature associating IL10RB and retinitis pigmentosa 75

IL10RB [ENSP00000290200]

Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Synonyms:  IL10RB,  IL10RBp,  hIL10RB,  F8WDX2,  H7C0Z5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM